urinary interleukin 6 and 8 concentrations in children with acute pyelonephritis, before and after treatment
نویسندگان
چکیده
background and aim: urinary tract infections (uti) are common cause of morbidity and mortality especially in young children around the world. pyelonephritis can lead to scar formation, and subsequent hypertension and renal failure. interleukins play a major role in renal scar formation following febrile pyelonephritis. the aim of this study was to investigate the level of urinary interleukin-6 (uil-6) and uil-8 concentrations during the acute phase of pyelonephritis and after two kinds of treatment. materials and methods: uil-6 and uil-8 concentrations were determined by enzyme immunoassay in 34 children with acute pyelonephritis who were treated with ceftriaxone plus steroids (case group) and in 20 patients treated with antibiotic alone (control group). cases and controls were age and sex matched. urine samples were obtained at the time of presentation prior to drug administration and at follow-up 72 hours after initiation of medication. creatinine concentrations were also determined, and cytokine/creatinine ratios were calculated. results: the differences between the cytokine/creatinine ratios in the initial urine samples and the follow-up samples were significant in the case group (p<0.001), but not for the controls. in addition, combined antibiotic and steroids significantly decreased uil-6 and uil-8 concentrations compared with antibiotic alone (p<0.05). conclusion: we conclude that steroids combined with antibiothics significantly decrease uil-6 and uil-8 levels in patients with acute pyelonephritis. this result can suggest that the clinical use of corticosteroids may prevent scar formation following pyelonephritis.
منابع مشابه
Urinary interleukin-8 in acute pyelonephritis of children: a before-after study.
INTRODUCTION The aim of this study was to assess urinary interleukin-8 (IL-8) levels in pyelonephritis and its relation with the clinical course of the infection and of inflammatory changes detected by renal scintigraphy. MATERIALS AND METHODS In this quasi-experimental before-after study, we evaluated 91 children aged 1 to 144 months (mean 34.4 +/- 35.2 months) with pyelonephritis. Inflammat...
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متن کاملبررسی سطح ادراری اینترلوکین‌های 6 و 8 در پیلونفریت حاد کودکان، قبل و بعد از درمان
Background and Aim: Urinary tract infections (UTI) are common cause of morbidity and mortality especially in young children around the world. Pyelonephritis can lead to scar formation, and subsequent hypertension and renal failure. Interleukins play a major role in renal scar formation following febrile pyelonephritis. The aim of this study was to investigate the level of urinary interleukin-6 ...
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پژوهش در پزشکیجلد ۳۲، شماره ۳، صفحات ۱۷۵-۱۸۱
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